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Sumoylation in Cellular Senescence and Aging.

L Gong, Q Sun, D W-C Li1

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, #54 Xianlie South Road, Guangzhou, Guangdong 510060,. China.

Current Molecular Medicine
|December 27, 2016
PubMed
Summary
This summary is machine-generated.

Sumoylation, a protein modification, changes with aging and cellular senescence. This review explores sumoylation's role in these aging processes.

Keywords:
RBSumoylationagingp53senescence

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Gerontology

Background:

  • Sumoylation is a reversible post-translational modification involving the conjugation of SUMO (small ubiquitin-like modifier) peptides to target proteins.
  • Alterations in global protein sumoylation and the expression of sumoylation pathway components are observed during organismal aging.
  • Key regulators of cellular senescence are known targets of sumoylation.

Purpose of the Study:

  • To review and summarize the current understanding of sumoylation's function in cellular senescence.
  • To consolidate information on the role of sumoylation in the aging process.

Main Methods:

  • Literature review of studies on sumoylation, cellular senescence, and aging.
  • Analysis of existing data on protein sumoylation patterns in aging organisms.
  • Examination of the sumoylation status of key senescence factors.

Main Results:

  • Sumoylation pathways and targets are significantly altered during aging.
  • Sumoylation plays a critical role in regulating cellular senescence.
  • Specific sumoylated proteins are implicated as key factors in senescence.

Conclusions:

  • Sumoylation is a crucial regulatory mechanism in both cellular senescence and organismal aging.
  • Understanding sumoylation provides insights into the molecular basis of aging and senescence.
  • Targeting sumoylation pathways may offer potential strategies for age-related interventions.