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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
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Advances in Micelle-based Drug Delivery: Cross-linked Systems
Ismail Alper Isoglu1, Yıldız Ozsoy2, Sevil Dincer Isoglu1
1Bioengineering Department, Faculty of Life and Natural Sciences, Abdullah Gül University, Kayseri, Turkey.
Current Topics in Medicinal Chemistry
|December 27, 2016
Summary
Cross-linked micelles offer improved drug delivery by preventing dissociation and enabling targeted release. This review details chemical methods for creating these advanced nanocarriers.
Area of Science:
- Polymer chemistry
- Nanotechnology
- Drug delivery systems
Background:
- Drug molecules face biological barriers like kidney filtration and RES clearance.
- Amphiphilic polymer micelles are promising nanocarriers but prone to dissociation, reducing therapeutic efficacy.
- Dissociation necessitates higher drug doses, increasing risks and costs.
Purpose of the Study:
- To review chemical methodologies for preparing cross-linked micelles.
- To highlight recent advancements in cross-linked micelle research for drug delivery.
- To address the limitations of conventional micelles in drug biodistribution and release.
Main Methods:
- Chemical synthesis of cross-linked micelles using various polymers.
- Design of micelles with cross-links in the core or shell for stability.
- Development of responsive cross-links (pH, reductive environment) for controlled drug release.
Main Results:
- Cross-linking prevents micelle dissociation in physiological conditions.
- Stabilized micelles enhance drug biodistribution and therapeutic outcomes.
- Responsive cross-links enable site-specific drug release, improving targeting and reducing side effects.
Conclusions:
- Cross-linked micelles represent a significant advancement over conventional micelles.
- Chemical strategies for creating stable and responsive micelles are crucial for effective drug delivery.
- Further research into cross-linked micelles promises enhanced therapeutic strategies.
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