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Beyond cost-effectiveness: Using systems analysis for infectious disease preparedness.

Charles Phelps1, Guruprasad Madhavan2, Rino Rappuoli3

  • 1University of Rochester, United States.

Vaccine
|December 27, 2016
PubMed
Summary
This summary is machine-generated.

Multi-criteria systems analysis offers a better approach to prioritizing health investments like Ebola vaccines. This method accounts for broader impacts beyond cost-effectiveness, improving real-world decision-making for global health challenges.

Keywords:
Cost-effectivenessEbolaGlobal healthInfectious diseasesPreparednessSystems analysisZika

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Area of Science:

  • Global Health
  • Health Policy
  • Vaccine Development

Background:

  • Ebola vaccines were historically low priority due to cost-effectiveness and profitability concerns.
  • Recent outbreaks dramatically shifted priorities for Ebola vaccines among international health agencies.
  • Traditional analyses failed to capture crucial real-world decision-making factors.

Purpose of the Study:

  • To demonstrate the utility of multi-criteria systems analysis for evaluating and prioritizing vaccine development.
  • To highlight limitations of cost-effectiveness and cost-benefit analyses in complex health scenarios.
  • To show how systems analysis can incorporate broader societal impacts often missed by traditional methods.

Main Methods:

  • Utilized Multi-Criteria Systems Analysis (MCSA).
  • Employed the SMART Vaccines framework to visualize and include "other factors" in decision-making.
  • Compared MCSA with traditional cost-effectiveness and cost-benefit analyses.

Main Results:

  • Standard analyses overlooked critical factors like inequality, disparity, and indirect effects on uninfected populations.
  • MCSA effectively incorporates diverse criteria, including social, economic, and public health considerations.
  • The SMART Vaccines approach demonstrated a more comprehensive evaluation of vaccine development priorities.

Conclusions:

  • Multi-criteria systems analysis provides a more robust framework for health policy and investment decisions than traditional methods.
  • Systems analysis is essential for addressing complex global health threats like Ebola and Zika, considering issues of equity and disparity.
  • Adopting systems analysis can lead to more informed and beneficial priority-setting processes for vaccine development and other health initiatives.