Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

53.0K
Overview
53.0K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

515
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
515
Bioequivalence studies: Biowaivers01:13

Bioequivalence studies: Biowaivers

360
In certain scenarios, in vitro dissolution tests can replace in vivo bioequivalence studies. This is particularly true when a drug product, though available in varying strengths, maintains proportional similarity in its active and inactive ingredients. In such cases, the need for in vivo bioequivalence studies for lower strength variants may be waived, provided dissolution tests and in vivo studies on the highest strength yield satisfactory results.Bioequivalence can be indicated through...
360
Cancer Vaccines01:30

Cancer Vaccines

1.2K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.2K
Clinically Relevant Drug Product Specifications: Methods of Establishment01:29

Clinically Relevant Drug Product Specifications: Methods of Establishment

277
Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...
277
Standards of Care I01:22

Standards of Care I

1.2K
Federal statutes profoundly impact nursing practice, providing critical guidelines to ensure patient care is equitable, accessible, and of the highest quality. The following laws address distinct aspects of healthcare provision and patient rights:
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mind the gap: Bayesian equipoise calibration of clinical trial designs.

Journal of biopharmaceutical statistics·2026
Same author

Toward Patient-Centric Digital Monitoring of Obstructive Sleep Apnea: Mixed Methods Study.

Journal of medical Internet research·2026
Same author

Scientists' call to action: Microbes, planetary health, and the Sustainable Development Goals.

Cell·2024
Same author

A conservative approach to leveraging external evidence for effective clinical trial design.

Pharmaceutical statistics·2023
Same author

A Lean Reverse Vaccinology Pipeline with Publicly Available Bioinformatic Tools.

Methods in molecular biology (Clifton, N.J.)·2023
Same author

Emerging roles of SARS-CoV-2 Spike-ACE2 in immune evasion and pathogenesis.

Trends in immunology·2023
Same journal

Vaccination policies for healthcare personnel in Europe, 2026.

Vaccine·2026
Same journal

A historical overview of the anti-vaccine movement and its public health implications.

Vaccine·2026
Same journal

Vaccine strategies and development before and during the 1968 H3N2 influenza pandemic.

Vaccine·2026
Same journal

Influence of correlated vaccination behaviors on estimates of COVID-19 vaccine effectiveness in older adults - VISION network, October 2023 - March 2024.

Vaccine·2026
Same journal

V-safe: Summary of findings reported after COVID-19 vaccination to a US CDC active safety surveillance system through June 2023.

Vaccine·2026
Same journal

In silico selection and in vivo evaluation of scoloptoxin SSD14, Rm-inositol monophosphatase, and Rm-neprilysin as potential anti-tick vaccines.

Vaccine·2026
See all related articles

Related Experiment Video

Updated: Mar 9, 2026

In Vitro ELISA Test to Evaluate Rabies Vaccine Potency
09:04

In Vitro ELISA Test to Evaluate Rabies Vaccine Potency

Published on: May 11, 2020

13.4K

Core values for vaccine evaluation.

James Kenneth Timmis1, Fabio Rigat2, Rino Rappuoli3

  • 1University of Freiburg, Fahnenbergplatz, D-79085 Freiburg i. Br., Germany.

Vaccine
|December 27, 2016
PubMed
Summary
This summary is machine-generated.

Health economic models often overlook key vaccine benefits. This study identified four core values—disease incidence, cost-effectiveness, mortality, and severity—for better vaccine evaluation and decision-making.

Keywords:
Core valuesDecision-makingGH2035Health Technology Assessment (HTA)Health policyMCDAVaccine evaluationVaccine policy

More Related Videos

Using Reference Reagents to Confirm Robustness of Cytokine Release Assays for the Prediction of Monoclonal Antibody Safety
06:37

Using Reference Reagents to Confirm Robustness of Cytokine Release Assays for the Prediction of Monoclonal Antibody Safety

Published on: September 15, 2023

1.2K
Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
06:26

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

3.2K

Related Experiment Videos

Last Updated: Mar 9, 2026

In Vitro ELISA Test to Evaluate Rabies Vaccine Potency
09:04

In Vitro ELISA Test to Evaluate Rabies Vaccine Potency

Published on: May 11, 2020

13.4K
Using Reference Reagents to Confirm Robustness of Cytokine Release Assays for the Prediction of Monoclonal Antibody Safety
06:37

Using Reference Reagents to Confirm Robustness of Cytokine Release Assays for the Prediction of Monoclonal Antibody Safety

Published on: September 15, 2023

1.2K
Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
06:26

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

3.2K

Area of Science:

  • Health economics
  • Vaccinology
  • Decision science

Background:

  • Current health economic models inadequately incorporate disease-specific criteria and benefits of vaccination.
  • This limits the utility of vaccine evaluation and decision-making processes.
  • Existing vaccine evaluation methods often lack standardization and transparency, hindering accountability.

Purpose of the Study:

  • To identify universal vaccine-disease considerations, termed Core Values.
  • To establish expert consensus on these Core Values for vaccine evaluation.

Main Methods:

  • Two Delphi technique studies were conducted.
  • Expert members of the global vaccine community with diverse professional backgrounds were surveyed.
  • Formal statistical analysis was used to identify attributes with strong agreement.

Main Results:

  • Four attributes achieved strong consensus among experts:
  • 1. Incidence of disease cases prevented annually.
  • 2. Cost-effectiveness, encompassing cost-benefit and cost-utility analyses.
  • 3. Disease mortality rate (case-fatality rate).
  • 4. Severity of the target disease, including risks of morbidity and mortality.

Conclusions:

  • It is feasible to establish a consensus on a specific set of Core Values for vaccine evaluation.
  • These Core Values can improve the standardization, transparency, and utility of health economic models in vaccine decision-making.