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High-sensitivity Troponin T Assay in Asymptomatic High Cardiovascular Risk Patients. The TUSARC Registry

Isabel Álvarez1, Luis Hernández2, Héctor García3

  • 1Medicina Familiar y Comunitaria, Hospital Santos Reyes, Aranda de Duero, Burgos, Spain.

Revista Espanola De Cardiologia (English Ed.)
|December 27, 2016
PubMed

Insights

High-sensitivity troponin T (Hs-TnT) was elevated in 32.9% of asymptomatic Spanish individuals with very high cardiovascular risk. Factors associated with elevated Hs-TnT included older age, male sex, and heart failure history.

Area of Science:

  • Cardiology
  • Biomarkers
  • Public Health

Background:

  • High-sensitivity troponin T assays (Hs-TnT) are increasingly used in clinical trials and general population studies.
  • Previous studies have focused on low cardiovascular risk (CVR) populations.
  • The prevalence and associated factors of elevated Hs-TnT in high-CVR asymptomatic individuals remain less understood.

Purpose of the Study:

  • To determine the prevalence of detectable and elevated Hs-TnT in a Spanish cohort of asymptomatic individuals with very high CVR.
  • To identify clinical, analytical, and treatment parameters associated with elevated Hs-TnT in this population.

Main Methods:

  • Analysis of Hs-TnT detection and elevation (≥99th percentile) in 646 asymptomatic Spanish individuals with very high CVR.
  • Multivariate analysis to identify independent predictors of elevated Hs-TnT.

Main Results:

  • Hs-TnT was detected in 645 out of 646 analyzed patients (99.8%).
  • Elevated Hs-TnT was observed in 212 patients (32.9%).
  • Independent associations with elevated Hs-TnT included male sex, older age, higher body mass index, insulin therapy, history of heart failure, and lower estimated glomerular filtration rate.

Conclusions:

  • A significant proportion (32.9%) of asymptomatic Spanish individuals with very high CVR exhibit elevated Hs-TnT.
  • Elevated Hs-TnT in this population is linked to demographic factors (age, sex), obesity, diabetes treatment, pre-existing heart failure, and impaired kidney function.
Abstract

Keywords:
Alto riesgo cardiovascularHigh cardiovascular riskHigh-sensitivity troponin TRegistroRegistryTroponina T ultrasensible

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