Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Importance of the biofilm matrix for the erosion stability of <i>Bacillus subtilis</i> NCIB 3610 biofilms.

RSC advances·2022
Same author

The structure and mechanical properties of articular cartilage are highly resilient towards transient dehydration.

Acta biomaterialia·2015
Same author

A single charge in the actin binding domain of fascin can independently tune the linear and non-linear response of an actin bundle network.

The European physical journal. E, Soft matter·2015
Same author

Draft Genome Sequence of the Biofilm-Producing Bacillus subtilis Strain B-1, Isolated from an Oil Field.

Genome announcements·2014
Same author

Adapting a commercial shear rheometer for applications in cartilage research.

The Review of scientific instruments·2014
Same author

Carbohydrate coating reduces adhesion of biofilm-forming Bacillus subtilis to gold surfaces.

Applied and environmental microbiology·2014

Related Experiment Video

Updated: Mar 9, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

2.0K

Controlled nanoparticle release from a hydrogel by DNA-mediated particle disaggregation.

C Nowald1, B T Käsdorf1, O Lieleg1

  • 1Department of Mechanical Engineering and Institute of Medical Engineering, Technical University of Munich, Boltzmannstrasse 11, 85748 Garching, Germany.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|December 27, 2016
PubMed
Summary

This study presents a novel drug delivery system for controlled, sequential release of multiple pharmaceuticals. The innovative approach utilizes osmotic pressure and DNA triggers for orchestrated drug liberation, reducing the need for repeated administrations.

Keywords:
DNA linkerDrug deliveryLiposomesNanoparticlesOsmotic pressure

More Related Videos

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

10.4K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

9.0K

Related Experiment Videos

Last Updated: Mar 9, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

2.0K
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

10.4K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

9.0K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Sequential drug administration is crucial for many pharmaceutical applications.
  • Current methods often involve multiple administrations, posing challenges for patient compliance and efficacy.
  • Developing a single system for controlled, sequential drug release remains a significant hurdle.

Purpose of the Study:

  • To develop a novel drug delivery system enabling orchestrated and controlled sequential release of multiple therapeutic agents.
  • To overcome the limitations of current sequential drug administration methods.
  • To create a versatile platform for advanced pharmaceutical applications.

Main Methods:

  • Combining osmotic pressure generation via control molecule depletion with DNA-triggered disaggregation of nanoparticle clusters.
  • Utilizing synthetic DNA sequences to control the release of molecules and nanoparticles.
  • Implementing the system within a gel environment for spatio-temporal control.

Main Results:

  • Achieved precise spatio-temporal control over the release of molecules and nanoparticles from a gel matrix.
  • Demonstrated a novel mechanism for orchestrated drug liberation from a single delivery system.
  • Successfully combined osmotic pressure and DNA-based triggers for controlled release.

Conclusions:

  • The presented strategy offers a viable solution for complex drug delivery, enabling controlled, sequential release.
  • This approach has significant implications for wound healing and sustained pharmaceutical release applications.
  • The developed system has the potential to reduce the frequency of drug administrations, improving patient outcomes.