Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

40.0K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.0K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.7K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.7K
Bone Disorders01:29

Bone Disorders

5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of mandibular cortical erosion with chronic periodontitis, apical periodontitis, and tooth fracture in Japanese women aged 40 years and older: An artificial intelligence-based analysis.

Osteoporosis and sarcopenia·2026
Same author

Beyond resorption: targeting osteoclast fusion and polarization to restore balanced bone remodeling.

Frontiers in pharmacology·2026
Same author

M cell-dependent commensal uptake confers encephalitogenic phenotypes on γδT17 cells in Peyer's patches.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Orthopedic referral rates following osteoporosis screening using dental panoramic radiography in female patients: A three-year prospective study.

Osteoporosis and sarcopenia·2026
Same author

The RANK/RANKL axis controls vascular dynamics in the bone marrow.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Anabolic effects of Sost deficiency partially offset Opg deficiency-induced catabolism in cortical bone.

Journal of bone and mineral metabolism·2025

Related Experiment Videos

[Topics for basic research(osteoclast and bone resorption)in ASBMR 2016.]

Nobuyuki Udagawa1

  • 1Department of Biochemistry Matsumoto Dental University, Japan.

Clinical Calcium
|December 27, 2016
PubMed
Summary
This summary is machine-generated.

This report highlights key basic research findings from the 2016 American Society for Bone and Mineral Research (ASBMR) meeting, focusing on osteoclast biology and bone resorption processes.

Related Experiment Videos

Area of Science:

  • Bone Biology
  • Osteoclast Research
  • Mineral Metabolism

Background:

  • The American Society for Bone and Mineral Research (ASBMR) 2016 meeting convened to discuss advancements in bone and mineral research.
  • Basic science presentations are crucial for understanding bone remodeling and diseases.

Purpose of the Study:

  • To summarize key topics presented in basic research at the ASBMR 2016 meeting.
  • To specifically highlight research on osteoclasts and bone resorption.

Main Methods:

  • Review of selected presentations from the ASBMR 2016 conference.
  • Focus on basic science research, particularly concerning osteoclast function and bone resorption mechanisms.

Main Results:

  • Key findings related to osteoclast differentiation, function, and regulation were presented.
  • New insights into the molecular mechanisms underlying bone resorption were discussed.

Conclusions:

  • The ASBMR 2016 meeting showcased significant progress in understanding osteoclast biology.
  • Further research into osteoclast pathways holds potential for therapeutic interventions in bone diseases.