Related Experiment Video
Updated: Mar 9, 2026
04:05
Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy
Published on: August 22, 2025
1.0K
Intragastric balloon as an adjunct to lifestyle intervention: a randomized controlled trial
A Courcoulas1, B K Abu Dayyeh2, L Eaton3
1Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
International Journal of Obesity (2005)
|December 27, 2016
Summary
The Orbera Intragastric Balloon combined with lifestyle changes significantly improved short-term weight loss compared to lifestyle intervention alone. However, adverse gastrointestinal events were frequent.
Area of Science:
- Bariatric interventions
- Clinical trials
- Obesity management
Background:
- Obesity is a significant public health concern requiring effective management strategies.
- Lifestyle interventions are a cornerstone of obesity treatment.
- Adjunctive therapies are being explored to enhance weight loss outcomes.
Purpose of the Study:
- To evaluate the safety and effectiveness of the Orbera Intragastric Balloon as an adjunct to lifestyle intervention.
- To compare weight loss outcomes between patients receiving the intragastric balloon plus lifestyle intervention versus lifestyle intervention alone.
Main Methods:
- A multicenter, randomized, open-label clinical trial involving 255 adults with a body mass index (BMI) of 30-40 kg/m².
- Participants were randomized to either endoscopic placement of an intragastric balloon plus lifestyle intervention or lifestyle intervention alone.
- Outcomes, including weight loss, were assessed up to 12 months, with balloon removal at 6 months.
Main Results:
- The intragastric balloon group achieved significantly greater weight loss at 6 months (-10.2%) compared to the lifestyle-only group (-3.3%) (P<0.001).
- This weight loss advantage persisted post-balloon removal, with the balloon group showing greater loss at 9 months (-9.1%) and 12 months (-7.6%) versus the control group (-3.4% and -3.1%, respectively).
- A higher percentage of subjects in the balloon group achieved substantial excess weight loss, though adverse gastrointestinal events like nausea and vomiting were common.
Conclusions:
- The Orbera Intragastric Balloon, when used with lifestyle intervention, leads to greater short-term weight loss compared to lifestyle intervention alone.
- Adverse gastrointestinal events are a common occurrence with intragastric balloon use.
- The findings suggest a potential benefit of intragastric balloons for short-term obesity management, but safety considerations are important.
Related Concept Videos
01:29Gastroesophageal Reflux Disease II: Clinical Features and Management
1.1K
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
1.1K
01:16Gastric Emptying
4.5K
Gastric emptying occurs when the stomach gradually releases chyme into the duodenum. When the stomach is distended, it triggers the release of gastrin, a hormone that promotes gastric acid secretion to aid in digestion. Additionally, stomach distension contributes to peristaltic waves that propel gastric contents toward the pyloric region. The gastroenteric reflex, on the other hand, primarily stimulates peristalsis in the intestines, facilitating the movement of contents further along the...
4.5K
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
992
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
992
01:23Binge Eating Disorders
647
Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
647