Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genetic Screens02:46

Genetic Screens

5.8K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.8K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

16.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
16.3K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

57
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
57
Genomics02:02

Genomics

41.2K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
41.2K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

19.2K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
19.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mathematical modeling of immune counter-regulation predicts efficacy of fractionated CD8<sup>+</sup> T cell dosing strategies.

Scientific reports·2026
Same author

White paper: standards for handling and analyzing plant pan-genomes.

F1000Research·2025
Same author

scHDeepInsight: a hierarchical deep learning framework for precise immune cell annotation in single-cell RNA-seq data.

Briefings in bioinformatics·2025
Same author

Voltage-matrix nanopore profiling for the discrimination of protein mixtures.

Chemical science·2025
Same author

The distinct roles of genome, methylation, transcription, and translation on protein expression in Arabidopsis thaliana resolve the Central Dogma's information flow.

Genome biology·2025
Same author

Towards blood on demand: Rapid post-thaw isolation of red blood cells from multicomponent cryoprotectants.

Cryobiology·2025

Related Experiment Video

Updated: Mar 9, 2026

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics
08:09

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics

Published on: June 17, 2012

20.6K

Developing integrated crop knowledge networks to advance candidate gene discovery.

Keywan Hassani-Pak1, Martin Castellote2, Maria Esch1

  • 1Rothamsted Research, Department of Computational and Systems Biology, UK.

Applied & Translational Genomics
|December 27, 2016
PubMed
Summary

Understanding crop gene function is key to improving food security. This study presents a new method for integrating diverse biological data into knowledge networks, aiding gene discovery for crop enhancement.

Keywords:
BioinformaticsCropNet, Crop knowledge networkData integrationGSKN, Genome-scale Knowledge NetworkGene discoveryKnowledge discovery, crop genomicsKnowledge networkRefNet, Reference knowledge network of model species

More Related Videos

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.8K
A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

3.8K

Related Experiment Videos

Last Updated: Mar 9, 2026

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics
08:09

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics

Published on: June 17, 2012

20.6K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.8K
A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

3.8K

Area of Science:

  • Genomics and Bioinformatics
  • Plant Science
  • Computational Biology

Background:

  • Enhancing crop productivity is crucial for global food security.
  • Understanding biological mechanisms underlying crop traits (yield, disease resistance, nutrient/water use efficiency) is essential.
  • Vast amounts of genomic data are available, but integrating them for functional insights is challenging due to data heterogeneity.

Purpose of the Study:

  • To present a general approach for building genome-scale knowledge networks.
  • To unify heterogeneous, interconnected datasets for effective knowledge mining and gene discovery.
  • To facilitate crop improvement through systematic, evidence-based gene discovery.

Main Methods:

  • Developed methods, workflows, and tools for creating and visualizing genome-scale knowledge networks.
  • Integrated diverse datasets from multiple databases, addressing variable quality and coverage.
  • Focused on major crop species, wheat and barley.

Main Results:

  • Successfully built and visualized genome-scale knowledge networks for wheat and barley.
  • Characterized the global properties of these knowledge networks.
  • Demonstrated the value of integrated data for biological discovery using an example linking seed size to a barley WRKY transcription factor.

Conclusions:

  • The developed approach provides a unified representation of complex biological data.
  • Open-source software (Ondex) and knowledge resources (knetminer) are available for broader use.
  • This work represents a significant step towards systematic gene discovery for crop improvement.