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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
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Focus on Nivolumab in NSCLC

Diego L Cortinovis1, Stefania Canova1, Marida Abbate1

  • 1SC Oncologia Medica, Ospedale San Gerardo , Monza , Italy.

Frontiers in Medicine
|December 27, 2016
PubMed

Immunotherapy is changing the treatment of non-small cell lung cancer (NSCLC). The PD-1 inhibitor nivolumab has demonstrated meaningful results in terms of efficacy with a good safety profile. The novel approach to treating NSCLC using immunotherapy still has unsolved questions and challenging issues. The main doubts regarding the optimal selection of the patient are the role of this drug in first line of treatment, the individualization of the correct methodology of radiologic assessment and efficacy analysis, the best management of immune-mediated adverse events, and how to overcome the immunoresistance. The aim of this review is to analyze literature data on nivolumab in lung cancer with a focus on critical aspects related to the drug in terms of safety, the use in clinical practice, and possible placement in the treatment algorithm.

Keywords:
NSCLCPD-1PDL1checkpoint inhibitorsimmunotherapynivolumab

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