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Recurrent rhinovirus detections in children following a rhinovirus-induced wheezing exacerbation: A retrospective

Sofie Halmø Hürdum1, Guicheng Zhang2, Siew-Kim Khoo3

  • 1School of Paediatrics and Child Health, The University of Western Australia, GPO Box D184, Perth, Western Australia, 6840, Australia; Department of Pulmonary Medicine, Hvidovre Hospital, University of Copenhagen, Kettegård Allé 30, 2650 Hvidovre, Denmark.

International Journal of Pediatrics and Child Health
|December 27, 2016
PubMed

Insights

Children with a parental history of asthma and/or allergy are more susceptible to recurrent rhinovirus (RV) infections, leading to increased wheezing exacerbations. This susceptibility is linked to prior or subsequent viral detections, particularly RV-C.

Area of Science:

  • Pediatric Respiratory Medicine
  • Viral Immunology
  • Epidemiology

Background:

  • Rhinovirus (RV) is a common cause of wheezing exacerbations in children.
  • Longitudinal susceptibility to viral infections after RV-induced wheezing is not well understood.
  • The influence of parental asthma and/or allergy on children's viral susceptibility requires investigation.

Purpose of the Study:

  • To determine if RV-induced wheezing exacerbations in children are associated with prior or subsequent viral detections.
  • To investigate the role of parental history of asthma and/or allergy in children's susceptibility to viral infections.
  • To analyze the specific impact of RV-A and RV-C in relation to parental history.

Main Methods:

  • Prospective recruitment of children presenting with acute wheeze.
  • Respiratory virus testing and retrospective data collection from hospital microbiology records.
  • Analysis of parental history of asthma and/or allergy as a defining factor.

Main Results:

  • Rhinovirus (RV) was detected in 69.2% of wheezing children, with RV-C being most prevalent (65.5%).
  • Children with parental asthma/allergy and RV at recruitment showed a 14-fold increased rate of subsequent RV detection.
  • Children without parental history exhibited a reduced incidence rate ratio for viral samples.

Conclusions:

  • Parental history of asthma and/or allergy may predispose children to increased susceptibility to recurrent symptomatic RV infections.
  • This finding highlights a potential link between genetic predisposition and viral respiratory illness severity.
  • Further research is warranted to elucidate the mechanisms behind this increased susceptibility.
Abstract

Keywords:
allergyasthmaattackchildhoodrespiratory viruswheeze

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