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Updated: Mar 9, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

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Electrocardiographic left ventricular hypertrophy predicts atrial fibrillation independent of left ventricular mass

Nikhil Patel1, Wesley T O'Neal2, S Patrick Whalen1

  • 1Section of Cardiology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
|December 27, 2016
PubMed

Insights

Electrocardiography-left ventricular hypertrophy (ECG-LVH) and echocardiography-left ventricular hypertrophy (echo-LVH) independently predict atrial fibrillation (AF). These findings suggest distinct electrophysiological abnormalities contribute to AF risk.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Preventive Medicine

Background:

  • Left ventricular hypertrophy (LVH) is a known cardiovascular risk factor.
  • The independent predictive value of ECG-LVH and echo-LVH for atrial fibrillation (AF) remains unclear.

Purpose of the Study:

  • To determine if ECG-LVH and echo-LVH independently predict incident AF.
  • To investigate the relationship between ECG-LVH, echo-LVH, and AF risk.

Main Methods:

  • Analysis of 4,904 participants from the Cardiovascular Health Study, free of baseline AF.
  • ECG-LVH defined by Minnesota Code Classification; echo-LVH defined by sex-specific left ventricular mass.
  • Cox regression used to assess the association of ECG-LVH and echo-LVH with incident AF.

Main Results:

  • ECG-LVH (4.6%) and echo-LVH (4.7%) were independently associated with incident AF (HR=1.50 and HR=1.39, respectively).
  • In a combined model, both ECG-LVH (HR=1.47) and echo-LVH (HR=1.36) remained significant predictors of AF.
  • Over 11.9 years median follow-up, 1,430 AF events were recorded.

Conclusions:

  • ECG-LVH predicts AF independently of left ventricular mass measured by echocardiography.
  • Cardiac electrophysiological abnormalities offer a distinct risk profile for predicting AF.
  • Both ECG and echocardiography findings of LVH contribute to AF risk prediction.
Abstract

Keywords:
atrial fibrillationepidemiologyleft ventricle

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