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Renal calyceal and pelvic contraction rhythms.

O A Yamaguchi¹, C E Constantinou

¹Department of Surgery, Stanford University Medical School, California 94305-5118.

The American Journal of Physiology

|October 1, 1989

Summary

Pig kidneys reveal a coordinated pacemaker system where calyces communicate to regulate urine flow to the renal pelvis. This intercalyceal coupling is essential for organized renal pelvic contractions.

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Area of Science:

Nephrology
Physiology
Urology

Background:

The renal pelvis and calyceal system coordinate to propel urine towards the bladder.
Understanding the pacemaker system of the kidney is crucial for diagnosing and treating urinary tract motility disorders.

Purpose of the Study:

To investigate the rhythmic activities within the porcine multicalyceal system.
To examine the coordination between calyceal contractions and renal pelvic contractions.

Main Methods:

Ex vivo perfusion of 15 pig kidneys via the renal artery.
Simultaneous pressure recording from the renal pelvis and three calyces.
Analysis of temporal and spatial organization of contraction rates and phase relationships.

Main Results:

Individual calyces exhibited rhythmic contractions at similar rates (approximately 13-14 min-1).
Evidence of coherent intercalyceal coupling was observed, including phase locking and phase oscillation.
Pelvic contractions were correlated with calyceal activity when coupling mechanisms were present, but not in their absence.

Conclusions:

The porcine kidney possesses a multicalyceal pacemaker system with coordinated activity.
Intercalyceal coupling plays a significant role in organizing renal pelvic contractions.
Disruption of this coupling mechanism impairs the correlation between calyceal and pelvic motility.

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