Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Indomethacin and lung maturity].

G Georgiev, S Avgarska

    Akusherstvo I Ginekologiia
    |January 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Indomethacin treatment in pregnant rats negatively impacted fetal lung maturation, indicated by altered amniotic fluid surfactant. Higher doses also led to gastrointestinal issues and fetal mortality.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Triaxiality of neutron-rich ruthenium nuclei studied by lifetime measurements.

    The European physical journal. A, Hadrons and nuclei·2026
    Same author

    Direct Evidence for the νd_{5/2} Orbital in ^{69}Ni: Implications for the N=40 Island of Inversion.

    Physical review letters·2026
    Same author

    Charge Radii Measurements of Exotic Tin Isotopes in the Proximity of N=50 and N=82.

    Physical review letters·2025
    Same author

    Reduction in Nuclear Size and Quadrupole Deformation of High-Spin Isomers of ^{127,129}In.

    Physical review letters·2025
    Same author

    Nuclear moments of indium isotopes reveal abrupt change at magic number 82.

    Nature·2022
    Same author

    Boulay et al. Reply.

    Physical review letters·2021

    Area of Science:

    • Pharmacology
    • Developmental Biology
    • Obstetrics

    Background:

    • Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used to manage pain and inflammation.
    • Premature infants may experience respiratory distress syndrome due to immature lung surfactant.
    • Understanding drug effects on fetal development is crucial for maternal and child health.

    Purpose of the Study:

    • To investigate the effects of indomethacin on fetal lung maturation in Wistar rats.
    • To assess the impact of different indomethacin dosages on amniotic fluid surfactant and fetal outcomes.

    Main Methods:

    • Pregnant Wistar rats were administered indomethacin (3 mg/kg or 5 mg/kg) for two days.
    • Animals were euthanized on days 18, 19, and 20 of gestation.

    Related Experiment Videos

  • Amniotic fluid surfactant was analyzed using the black foam film method.
  • Maternal and fetal gastrointestinal tracts were examined for abnormalities.

    • Main Results:

    • Indomethacin administration resulted in threshold dilution of amniotic fluid surfactant in treated groups compared to controls.
    • Higher doses of indomethacin caused changes in the maternal and fetal gastrointestinal tracts.
    • Fetal mortality was observed in some fetuses following higher-dose indomethacin administration.

    Conclusions:

    • Indomethacin exposure during pregnancy adversely affects fetal lung maturation.
    • The drug's effects on surfactant may contribute to respiratory complications in newborns.
    • Indomethacin poses risks to fetal development, including gastrointestinal disturbances and mortality.