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Cold urticaria in Saudi Arabia.

J N Moreno¹, H A Harfi

¹Section of Allergy & Clinical Immunology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.

Annals of Allergy

|October 1, 1989

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Two cases of cold-induced urticaria were observed in Saudi Arabia over 8 years, suggesting a lower prevalence. Ketotifen proved effective for a patient unresponsive to cyproheptadine.

Area of Science:

Dermatology
Allergy and Immunology

Background:

Cold-induced urticaria (CIU) is a rare physical urticaria triggered by cold exposure.
Prevalence data for CIU varies globally, with limited information from the Middle East.

Observation:

Two cases of CIU were documented over an 8-year period at a tertiary care center in Saudi Arabia.
This observation suggests a potentially lower prevalence of CIU in Saudi Arabia compared to other regions.

Findings:

One patient with CIU showed no response to cyproheptadine, a common antihistamine.
The same patient experienced significant symptom relief with ketotifen, a mast cell stabilizer and antihistamine.

Implications:

The findings highlight the need for further epidemiological studies on CIU prevalence in Saudi Arabia.

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Ketotifen may represent a viable therapeutic option for CIU cases refractory to standard treatments.