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Published on: July 20, 2014
NFAT1 promotes cell motility through MMP-3 in esophageal squamous cell carcinoma
Peinan Chen1, Zhengzheng Shan2, Jianbo Zhao3
1Department of Thoracic Surgery, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, Henan, China; The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, Henan, China.
Abstract:
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors and the prognosis of patients remains poor. Increasing evidence suggests that nuclear factor of activated T cell (NFAT1) plays an important role in the development and progression of cancers. Herein, we show that NFAT1 was overexpressed in human ESCC, which was significantly associated with advanced tumor stage and lymph node metastasis. Functional studies found that NFAT1 silencing could suppress cell migration and invasion through MMP-3. The data therefore suggest that NFAT1 plays an important adverse role in the development and progression of ESCC, implicating possible application in clinics as a biomarker and a potential new therapeutic target.
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