[Effect of WT1 Gene High Expression and CD34+ and Auer+ on Prognosis of Acute Myeloid Leukemia]
Zhong-Li Hu1, Bao-Jun Huang1, Shao-Jun Pan2
1Department of Immunology, College of Basic Medical Sciences, Anhui Medical University, Hefei 230000, Anhui Province, China.
Objective:
To explore the clinical significance of WT1 expression level in patient with AML non-M3,understand the biological characteristics of Auer+ and CD34+ AML and its effects on first induced remission rate and prognosis.
Methods:
The RQ-PCR was used to detect the WT1 expression levels in 92 patients suffering AML non-M3; the relationship between the CR1 and OS was analysed and the differences of CR1 and OS in AML with Auer+ and Auer-,CD34+ and CD34- were compared.
Results:
AML with WT1 high expression level at first visit had quite lower CR1 (P<0.05). AML with CD34+ had quite lower CR1 (P<0.05). Compared with Auer- patients, CR1 of Auer+ CML patients was higher (P<0.05), the OS of AML patients with WT1 high expression level was lower than that of the AML patients with low expression level of WT1, and with significant differences (P<0.05), the OS of AML patients with CD34+ was lower than that of AML patients with CD34-, and with significant differences (P<0.05). There was no obvious difference in OS between the AML patients with Auer+ and Auer-.
Conclusion:
High expression level of WT1 and CD34+ in AML patients suggests the poor prognosis. The Auer positive only relats with CR1, and does not relate with OS.
