[PET-CT Manifestation and Clinical Analysis of Waldenstrom Macroglobulinemia]

To investigate the PET-CT manifestation and clinical features of patients with Waldenstrom macroglobulinemia(WM) .

The clinical features, laboratorial examination results and PET-CT manifestation of 12 patients with WM were analyzed retrospectively.

The average age of 12 patients with WM was 63.5 years old, the most common incipient symptoms were fatigue and hyperviscosity syndrome. The median SUV_max of bone marrow was 4.9 (range of 2.1 to 21.9), with diffusely increased ¹⁸F-FDG uptake in all the patients. In 6 patients, the median SUV_max of splenomegaly and lymphadenectasis was 3.2 (range of 2.3 to 5.2) and 5.2 (range of 3.6 to 11.2), respectively. The SUV_max of bone marrow, splenomegaly and lymphadenectasis did not related with white blood cell count, hemoglobin level, blood platelet count, β2- microglobulin level and serum monoclonal IgM of such patients, respectively (both P>0.5). In univariate analysis, serum monoclonal IgM and the SUV_max of lymphadenectasis were found to be the prognostic factors (both P<0.5).

The ¹⁸F-FDG PET-CT feature of Waldenstrom macroglobulinemia has some characteristics which are helpful for setting up the clinical therapeutic schedule.