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Updated: Mar 9, 2026
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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
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PIK3CA mutations as prognostic factor in squamous cell lung carcinoma
Marc McGowan1, Aleksandra Silye Hoven2, Marius Lund-Iversen2
1Dept of Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway.
Lung Cancer (Amsterdam, Netherlands)
|December 28, 2016
Summary
PIK3CA gene mutations may improve survival in early-stage lung squamous cell carcinoma. These mutations were linked to longer overall survival and time to relapse in patients, suggesting a potential survival advantage.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Genetics
Background:
- PIK3CA gene mutations are common in lung squamous cell carcinomas.
- The prognostic significance of PIK3CA mutations in early-stage lung cancer remains unclear.
Purpose of the Study:
- To investigate the prognostic role of PIK3CA mutations in early-stage lung squamous cell carcinoma.
- To explore the relationship between PIK3CA mutations and other markers, such as PD-L1 expression.
Main Methods:
- Tumor tissue from 308 early-stage lung squamous cell carcinoma patients was analyzed.
- PIK3CA mutation status was determined using SnapShot and Cobas methods.
- PD-L1 expression was assessed via immunohistochemistry, with survival outcomes tracked over a median of 67.6 months.
Main Results:
- PIK3CA mutations were identified in 11.4% of patients, predominantly in exon 20.
- Patients with PIK3CA mutations demonstrated significantly longer overall survival (p=0.042) and time to relapse (p=0.030).
- This improved time to relapse was also observed in stage I patients (p=0.044), and PD-L1 expression was less frequent in mutated cases.
Conclusions:
- PIK3CA mutations may be associated with a survival advantage in early-stage lung squamous cell carcinoma.
- Further research is warranted to confirm these findings and their clinical implications.
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