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Related Concept Videos

Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

80
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
80
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

71
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
71
Drug Delivery: Overview01:16

Drug Delivery: Overview

1.1K
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
1.1K
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
60
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

145
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
145
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Topical and cutaneous delivery using nanosystems.

M S Roberts1, Y Mohammed2, M N Pastore3

  • 1Therapeutics Research Centre, School of Medicine, The University of Queensland, Translational Research Institute, QLD, 4102, Australia; School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|December 28, 2016
PubMed
Summary
This summary is machine-generated.

Nanosystems enhance topical drug delivery for challenging molecules like peptides and proteins. While promising, widespread clinical use requires rigorous safety validation for these advanced nanotechnologies.

Keywords:
Colloidal nanocarrier systemsCutaneous deliveryNanoparticlesNanosystemsTopical delivery

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Area of Science:

  • Dermatology and Nanotechnology
  • Pharmaceutics and Drug Delivery

Background:

  • Topical and cutaneous delivery aims to deliver substances to the skin for safe and effective outcomes.
  • The intact skin barrier normally limits delivery to small, lipophilic molecules, excluding peptides, proteins, and vaccines.
  • Nanosystems offer a solution for delivering these previously inaccessible therapeutic agents.

Purpose of the Study:

  • To review the increasing use of nanosystems for topical and cutaneous delivery.
  • To highlight novel technologies enabling enhanced skin penetration.
  • To discuss the challenges and safety considerations for clinical translation of nanosystems.

Main Methods:

  • Review of current literature on nanosystems for skin delivery.
  • Analysis of novel fabrication techniques and minimally invasive systems.
  • Examination of safety aspects of nanotechnologies in dermatological applications.

Main Results:

  • Nanosystems are increasingly utilized for delivering challenging molecules (peptides, proteins, vaccines) via topical and cutaneous routes.
  • Novel technologies, including minimally invasive systems and advanced fabrication, are driving progress.
  • Despite numerous nanosystems in development and clinical trials, few have reached clinical practice.

Conclusions:

  • Nanosystems show significant potential for improving topical and cutaneous drug delivery, especially for large or charged molecules.
  • The translation of nanosystems into clinical practice is hindered by the need for comprehensive safety data.
  • Further research and rigorous safety assessments are crucial for the successful clinical adoption of nanodelivery systems.