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Influence of particle properties on powder bulk behaviour and processability
Umang V Shah1, Vikram Karde2, Chinmay Ghoroi2
1Surfaces and Particle Engineering Laboratory (SPEL), Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK(1).
International Journal of Pharmaceutics
|December 28, 2016
Summary
Understanding powder properties is key to pharmaceutical processing. This review explores how particle properties, environmental conditions, and processing methods influence interparticle interactions and powder behavior.
Area of Science:
- Pharmaceutical Science
- Materials Science
Background:
- Interparticle interactions are critical in pharmaceutical powder processing.
- Identifying factors influencing these interactions remains challenging.
- Factors include powder properties, environmental conditions, and processing parameters.
Purpose of the Study:
- To review recent advances in understanding interparticle interactions.
- To focus on the impact of particle properties on powder behavior.
- To highlight the influence of particle processing on properties and interactions.
Main Methods:
- Literature review of recent advances in powder science.
- Analysis of the interplay between particle properties, processing, and interactions.
- Discussion of strategies for controlling interparticle interactions through processing.
Main Results:
- Particle properties significantly affect interparticle interactions and bulk powder behavior.
- Particle processing routes and parameters directly influence particle properties.
- Tailoring particle properties via processing enables control over interparticle interactions.
Conclusions:
- A mechanistic understanding of combined factors affecting interparticle interactions is needed.
- Particle processing offers a route to control interparticle interactions for desired powder behavior.
- Future research should focus on developing novel particle processing approaches.
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