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[Target Therapy in Unresectable or Metastatic Colorectal Cancer]

Jae Hyun Kim1, Seun Ja Park1

  • 1Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.

The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi
|December 28, 2016
PubMed

Insights

Targeted therapies like anti-EGFR and anti-VEGF agents improve survival for metastatic colorectal cancer (CRC). Personalized treatment strategies are essential for unresectable or metastatic CRC patients.

Area of Science:

  • Oncology
  • Gastroenterology
  • Pharmacology

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer death in Korea.
  • Metastatic CRC survival remains limited despite treatment advances.
  • Biologic agents targeting EGFR and VEGF offer clinical benefits.

Purpose of the Study:

  • To review the mechanisms of targeted therapy for metastatic CRC.
  • To summarize key clinical trial results for targeted agents.
  • To outline clinical practice guidelines for unresectable or metastatic CRC.

Main Methods:

  • Literature review of targeted therapies for metastatic CRC.
  • Analysis of clinical trial data for anti-EGFR and anti-VEGF agents.
  • Synthesis of current clinical practice guidelines.

Main Results:

  • Anti-EGFR (cetuximab, panitumumab) and anti-VEGF (bevacizumab, aflibercept, ramucirumab, regorafenib) agents extend survival with chemotherapy.
  • Anti-EGFR agents show significant efficacy in RAS wild-type metastatic CRC.
  • Personalized treatment based on patient characteristics is crucial.

Conclusions:

  • Targeted therapies have significantly improved outcomes for metastatic CRC.
  • RAS mutational status is a key factor in selecting anti-EGFR therapy.
  • Future CRC treatment requires personalized strategies incorporating clinical and biological features.
Keywords:
Colorectal neoplasmsMolecular targeted therapyNeoplasm metastasis

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