Related Experiment Video
Updated: Mar 9, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Pyran Rings Containing Polyketides from Penicillium raistrickii
Li-Ying Ma1, De-Sheng Liu2, De-Guo Li3
1College of Pharmacy, Binzhou Medical College, Yantai 264003, China. maliyingbz@163.com.
Abstract:
Five new pyran rings containing polyketides, penicipyrans A-E (1-5), together with the known pestapyrone A (6), were isolated from the saline soil-derived Penicillium raistrickii. Their structures were determined by interpretation of NMR and HRESIMS data. The absolute configurations of compounds 4 and 5 were established by the modified Mosher's method and single-crystal X-ray diffraction analysis, respectively. These compounds possessed high structural diversity including two α-pyrones (1, 2), three isocoumarins (3, 4, 6), and one dihydropyran derivative (5). Among them, Compound 5 exhibited cytotoxicity against HL-60 and K562 cell lines with IC50 values of 4.4 and 8.5 μM, respectively.
More Related Videos
07:59A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
09:08From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Related Concept Videos
Five-Membered Heterocyclic Aromatic Compounds: Overview
Basicity of Heterocyclic Aromatic Amines
Bacterial Phylum Spirochaetes
Fungal Phylum Basidiomycota
Bacterial Phylum Planctomycetes
Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)