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The Evidence for Evolution02:55

The Evidence for Evolution

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Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
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Introduction to Epidemiology01:26

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Epidemiology, known as the cornerstone of public health, involves studying the distribution and determinants of health-related events in defined populations and applying these insights to control health issues. This is essential for understanding how diseases spread, identifying populations at greater risk, and implementing measures to control or prevent outbreaks. Epidemiology addresses not only infectious diseases but also non-communicable conditions like cancer and cardiovascular disease,...
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In the case of systematic errors, the sources can be identified, and the errors can be subsequently minimized by addressing these sources. According to the source, systematic errors can be divided into sampling, instrumental, methodological, and personal errors.
Sampling errors originate from improper sampling methods or the wrong sample population. These errors can be minimized by refining the sampling strategy. Defective instruments or faulty calibrations are the sources of instrumental...
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Significance Testing: Overview01:04

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Significance testing is a set of statistical methods used to test whether a claim about a parameter is valid. In analytical chemistry, significance testing is used primarily to determine whether the difference between two values comes from determinate or random errors. The effect of a particular change in the measurement protocol, analyst, or sample itself can cause a deviation from the expected result. In the case of a suspected deviation/outlier, we need to be able to confirm mathematically...
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Detection of Black Holes01:10

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Although black holes were theoretically postulated in the 1920s, they remained outside the domain of observational astronomy until the 1970s.
Their closest cousins are neutron stars, which are composed almost entirely of neutrons packed against each other, making them extremely dense. A neutron star has the same mass as the Sun but its diameter is only a few kilometers. Therefore, the escape velocity from their surface is close to the speed of light.
Not until the 1960s, when the first neutron...
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Cause and Effect01:53

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While variables are sometimes correlated because one does cause the other, it could also be that some other factor, a confounding variable, is actually causing the systematic movement in our variables of interest. For instance, as sales in ice cream increase, so does the overall rate of crime. Is it possible that indulging in your favorite flavor of ice cream could send you on a crime spree? Or, after committing crime do you think you might decide to treat yourself to a cone?
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Related Experiment Video

Updated: Mar 9, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

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Evidence and evidence gaps - an introduction.

Gabriele Dreier1, Jan Löhler2

  • 1German Study Center of Oto-Rhino-Laryngology, Head and Neck Surgery, Bonn, Germany; Clinical Trials Unit of the Medical Center - University of Freiburg, Germany.

GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
|December 28, 2016
PubMed
Summary

Evidence-based medicine (EBM) is crucial for optimal patient care. The German Study Center of Oto-Rhino-Laryngology (DSZ-HNO) was founded to support clinicians in generating, processing, and implementing EBM in daily practice.

Keywords:
clinical trial unitevidence-based medicinemedical devicesregistrytransparency

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Area of Science:

  • Otorhinolaryngology
  • Evidence-Based Medicine
  • Clinical Research

Background:

  • Medical treatment relies on physician expertise and existing evidence from clinical trials.
  • Systematic reviews and public availability of all trial results are essential to avoid publication bias.
  • Evidence-based medicine (EBM) has grown in importance over the last 25 years, with key organizations like Cochrane Germany and the German Network for Evidence-based Medicine (DNEbM) established.

Conclusions:

  • The DSZ-HNO provides a feasible infrastructure to support physicians in hospitals and private practices.
  • Methodological expertise is now accessible to aid clinical research and the integration of EBM into routine care.
  • The center aims to enhance the generation, processing, and transfer of evidence within the ENT field.