Related Experiment Video
Updated: Mar 9, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
Pure Cold-Induced Cholinergic Urticaria in a Pediatric Patient
Tina Abraham1, David P McGarry2, John Frith1
1Department of Allergy and Immunology, University Hospitals, Regional Hospitals, Richmond Heights, OH, USA.
Abstract:
Cold urticaria and cholinergic urticaria are two distinct entities. The presentation of exclusive cold-induced cholinergic urticaria is very rare. The patient described herein had experienced urticaria in the exclusive setting of exercising in a cold environment. Urticarial testing including laboratory and in-office testing was all negative. The patient has prevented urticaria symptoms with oral antihistamine therapy. Pure cold-induced cholinergic urticaria is rarely described in literature. This form of urticaria has yet to be described in a pediatric patient.
Related Concept Videos
Allergic Reactions: Anaphylaxis
Allergic Reactions
Direct-Acting Cholinergic Agonists: Therapeutic Uses
Hypersensitivity Reactions: Immune-Complex Reactions
Depolarizing Blockers: Pharmocokinetics
Drug Toxicity: Allergic Reactions

