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Published on: September 4, 2017
Multiple confidence intervals for selected parameters adjusted for the false coverage rate in monotone dose-response
Jianan Peng1, Wei Liu2, Frank Bretz3,4
1Department of Mathematics and Statistics, Acadia University, Wolfville, NS, Canada B4P 2R6.
Abstract:
Benjamini and Yekutieli () introduced the concept of the false coverage-statement rate (FCR) to account for selection when the confidence intervals (CIs) are constructed only for the selected parameters. Dose-response analysis in dose-response microarray experiments is conducted only for genes having monotone dose-response relationship, which is a selection problem. In this paper, we consider multiple CIs for the mean gene expression difference between the highest dose and control in monotone dose-response microarray experiments for selected parameters adjusted for the FCR. A simulation study is conducted to study the performance of the method proposed. The method is applied to a real dose-response microarray experiment with 16, 998 genes for illustration.
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