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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Drug Discovery: Overview01:26

Drug Discovery: Overview

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Treatment Resistant Cancers02:56

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

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Drug Repurposing in Anticancer Reagent Development.

Peng-Chen Chen1, Xaiolong Liu2, Yao Lin3

  • 1College of Life Sciences, Fujian Normal University, Fuzhou, Fujian Province. China.

Combinatorial Chemistry & High Throughput Screening
|December 28, 2016
PubMed
Summary
This summary is machine-generated.

Drug repurposing offers a faster, cheaper alternative to traditional cancer drug development. While many non-cancer drugs show promise, more evidence is needed for clinical trials.

Keywords:
Drug repurposingcancercellular experimentsmechanismsignaling pathwaytarget

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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
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Last Updated: Mar 9, 2026

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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

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Area of Science:

  • Oncology
  • Pharmacology
  • Drug Discovery

Background:

  • Cancer remains a significant global health threat, with poor prognosis for unresectable types.
  • Advances in surgery, chemotherapy, and radiotherapy have improved outcomes for some cancers, but new therapeutic agents are crucial.
  • Conventional anticancer drug development is expensive, time-consuming, and high-risk, with limited new drugs reaching the market annually.

Purpose of the Study:

  • This review synthesizes the latest advancements in chemotherapy drug repurposing for cancer treatment.
  • It highlights the potential of utilizing existing drugs for new oncological applications.

Main Methods:

  • Literature review of recent studies on drug repurposing in cancer research.
  • Analysis of evidence supporting the efficacy of non-cancer drugs against various cancer types.

Main Results:

  • Drug repurposing presents a more economical and expedited pathway compared to de novo drug development.
  • Numerous non-cancer drugs are currently under investigation for their anticancer properties.

Conclusions:

  • While promising, many repurposed drug candidates lack sufficient evidence for progression into clinical cancer trials.
  • Identifying effective candidates and bridging the gap between preclinical research and clinical application remain significant challenges.