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Developmental Phases of Anticancer Screening Models.

Khaldoon Alsamman1, Omar S El-Masry2

  • 1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Dammam, P.O. Box: 2435, Dammam 31441. Saudi Arabia.

Combinatorial Chemistry & High Throughput Screening
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PubMed
Summary

Developing advanced cancer screening models is crucial for improving chemotherapy and drug development. This review covers traditional and novel models, including 2D, 3D, cancer stem cell, non-mammalian, and virtual screening tools.

Keywords:
AnticancerDrosophilaZebrafishdrug discoveryscreening modelvirtual screeningyeast

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Area of Science:

  • Oncology
  • Pharmacology
  • Biotechnology

Background:

  • Anticancer drug development relies heavily on effective screening models.
  • Traditional in vivo models are being replaced by more advanced cell-based assays.
  • Improving the predictive accuracy of screening models is essential for clinical success.

Purpose of the Study:

  • To review the evolution of anticancer screening models.
  • To discuss various screening model types, including 2D, 3D, cancer stem cell, and non-mammalian models.
  • To highlight the role of virtual screening in anticancer drug discovery.

Main Methods:

  • Review of developmental phases of anticancer screening models.
  • Exemplification of different screening model types.
  • Discussion of virtual screening tools.

Main Results:

  • Anticancer screening models have progressed from in vivo to sophisticated cell-based assays.
  • Diverse models like 2D, 3D, cancer stem cell, and non-mammalian systems offer improved predictive capabilities.
  • Virtual screening presents a promising computational approach for drug development.

Conclusions:

  • Continuous development of screening models is vital for advancing cancer therapy.
  • A range of models, from in vitro to in silico, are essential for comprehensive anticancer drug evaluation.
  • The ultimate goal is to enhance the reliability of screening models in predicting clinical outcomes.