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Cutaneous Bipolaris spicifera infection.

B F Straka1, P H Cooper, B A Body

  • 1Department of Dermatology, University of Virginia Health Sciences Center, Charlottesville 22908.

Archives of Dermatology
|October 1, 1989
PubMed
Summary

Bipolaris spicifera, a rare cause of human skin infection, was identified in a leukemia patient with a leg ulcer. Successful treatment involved surgery, skin grafting, and antifungal medication.

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Area of Science:

  • Mycology
  • Dermatology
  • Infectious Diseases

Background:

  • Bipolaris spicifera is a dematiaceous fungus seldom documented as a cause of human cutaneous infections.
  • Fungal skin infections can pose challenges, particularly in immunocompromised individuals.

Observation:

  • A leukemia patient presented with a persistent, non-healing leg ulcer post-trauma.
  • Histopathology showed nonpigmented, septate fungal hyphae within the ulcer's necrotic tissue.
  • Fungal cultures produced characteristic gray-black colonies with a black reverse.

Findings:

  • Microscopic analysis confirmed dematiaceous, oblong conidia, identifying the fungus as Bipolaris spicifera.
  • The clinical presentation and laboratory findings were consistent with a Bipolaris spicifera cutaneous infection.

Implications:

  • This case highlights Bipolaris spicifera as a potential pathogen in human cutaneous infections, especially in immunocompromised hosts.
  • Effective management involved a multimodal approach including surgical intervention and antifungal therapy (amphotericin B).
  • Further research into Bipolaris spicifera's pathogenicity and treatment strategies is warranted.

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