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One-Pot Synthesis of Rotationally Restricted, Conjugatable, BODIPY Derivatives from Phthalides
Mayca Del Río1, Fernando Lobo1, J Cristobal López1
1Instituto de Química Orgánica General, IQOG-CSIC , Juan de la Cierva 3, 28006 Madrid, Spain.
Abstract:
O-Ethylation of phthalides with Meerwein's reagent followed by reaction of the ensuing salts with pyrrole, results in the formation of 5-alkoxy-5-phenyl dipyrromethane derivatives, which function as ready precursors of ortho-substituted 8-aryl BODIPY derivatives by reaction with borontrifluoride etherate, an overall process that can be carried out in a one-pot operation.
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