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Rat Mammary Epithelial Cell Transplantation into the Interscapular White Fat Pad
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Cancer Risk after Fat Transfer: A Multicenter Case-Cohort Study
Terence M Myckatyn1,2, I Janelle Wagner1,2, Babak J Mehrara1,2
1St. Louis, Mo.; Chapel Hill, N.C.; New York, N.Y.; Houston, Texas; Chicago and Arlington Heights, Ill.; Boston, Mass.; and Columbus, Ohio.
Plastic and Reconstructive Surgery
|December 28, 2016
Summary
Fat transfer after mastectomy with breast reconstruction does not increase cancer recurrence risk. This study found no association between fat grafting and disease recurrence in patients with invasive breast cancer.
Area of Science:
- Oncology
- Plastic Surgery
- Regenerative Medicine
Background:
- Fat transfer is a common technique for postmastectomy breast reconstruction.
- Concerns exist regarding the potential for fat transfer to promote breast cancer recurrence.
- Adipocytes and adipocytokines may influence breast cancer cell activity.
Purpose of the Study:
- To investigate the association between fat transfer and cancer recurrence in patients with invasive breast cancer.
- To evaluate the safety of fat grafting in the context of breast reconstruction after mastectomy.
Main Methods:
- A multicenter case-cohort study included patients who underwent mastectomy and immediate breast reconstruction.
- Eligibility criteria included invasive ductal carcinoma (stages I-III) diagnosed between 2006-2011.
- Cox proportional hazards regression analyzed the association between fat transfer and time to recurrence.
Main Results:
- The unadjusted hazard ratio for fat transfer and disease recurrence was 0.99 (95% CI, 0.56-1.7).
- After adjusting for clinical factors, the hazard ratio remained 0.97 (95% CI, 0.54-1.8).
Conclusions:
- Fat transfer was not associated with an increased risk of cancer recurrence in this cohort.
- The findings suggest that fat grafting is a safe option for breast reconstruction in patients with a history of invasive breast cancer.
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