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Modified-Release Drug Delivery Systems: Stimuli-Activated

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Hydrogels for Therapeutic Delivery: Current Developments and Future Directions.

Sytze J Buwalda¹, Tina Vermonden², Wim E Hennink²

¹Institute of Biomolecules Max Mousseron, Department of Artificial Biopolymers, Faculty of Pharmacy, UMR 5247, CNRS-University of Montpellier-ENSCM , Montpellier, France.

Biomacromolecules

|December 29, 2016

Summary

This summary is machine-generated.

Hydrogels offer advanced controlled therapeutic release via their water-swollen networks. This perspective highlights innovations in stimuli-responsive hydrogels, nanogels, and 3D printed systems for drug delivery.

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Area of Science:

Biomaterials Science
Polymer Chemistry
Bioengineering

Background:

Hydrogels are versatile materials for embedding and releasing therapeutic agents due to their water-swollen network structure.
Recent progress in organic chemistry, polymer science, bioengineering, and nanotechnology has significantly advanced hydrogel applications in drug delivery.

Purpose of the Study:

To provide a perspective on the current state-of-the-art in hydrogels for therapeutic delivery.
To highlight key emerging areas and future directions in the field.

Main Methods:

Review of recent advances in hydrogel synthesis and application for drug delivery.
Focus on specific innovative topics such as bioorthogonal cross-linking, multicomponent hydrogels, stimuli-responsive hydrogels, nanogels, and 3D printed hydrogels.

Main Results:

Identified several exciting developments including novel cross-linking methods and advanced hydrogel architectures.
Explored the potential of nanogels and 3D printed hydrogels for precise therapeutic delivery.
Discussed challenges in translating academic research to clinical applications.

Conclusions:

Hydrogels represent a rapidly evolving field with significant potential for advanced therapeutic delivery systems.
Overcoming translational challenges is crucial for clinical implementation of these innovative hydrogel technologies.