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Updated: Mar 9, 2026

Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse Model

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Two new compounds from Atractylodes macrocephala with neuroprotective activity.

Na Zhang¹, Chao Liu¹, Tie-Min Sun²

¹a College of Pharmacy , Liaoning University of Traditional Chinese Medicine , Dalian 116600 , China.

Journal of Asian Natural Products Research

|December 29, 2016

Summary

Researchers isolated eight compounds from Atractylodes macrocephala Koidz, including two novel compounds. All compounds demonstrated neuroprotective effects against MPP+-induced SH-SY5Y cells, suggesting therapeutic potential.

Keywords:

Atractylodes macrocephala atractylenolide neuroprotective effect

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Area of Science:

Natural Product Chemistry
Neuropharmacology
Medicinal Chemistry

Background:

Atractylodes macrocephala Koidz is a traditional medicinal herb.
Neurodegenerative diseases pose a significant health challenge.
Identifying novel neuroprotective agents is crucial.

Purpose of the Study:

To isolate and characterize compounds from Atractylodes macrocephala Koidz.
To evaluate the neuroprotective potential of isolated compounds.
To identify novel compounds with therapeutic applications.

Main Methods:

Isolation using silica gel, ODS column chromatography, and preparative HPLC.
Structure elucidation via 1D, 2D NMR, and circular dichroism.
Neuroprotection assay using MTT colorimetry on MPP+-induced SH-SY5Y cells.

Main Results:

Eight compounds were isolated, with compounds 6 and 8 identified as novel.
All eight isolated compounds exhibited neuroprotective activity.
Compounds demonstrated a protective effect against MPP+-induced neurotoxicity in SH-SY5Y cells.

Conclusions:

Atractylodes macrocephala Koidz is a source of potentially neuroprotective compounds.
Novel compounds 6 and 8 warrant further investigation for neurodegenerative disease treatment.
The study supports the ethnobotanical use of Atractylodes macrocephala Koidz.