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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
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Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
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Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
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Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
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Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
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A Child with Debilitating Pruritus.

Nikhil Sonthalia1, Samit S Jain1, Vinay B Pawar1

  • 1Department of Gastroenterology; Topiwala National Medical College and BYL Nair Ch Hospital , Mumbai, Maharashtra, India.

Clinics and Practice
|December 29, 2016
PubMed
Summary
This summary is machine-generated.

A rare case of progressive familial intrahepatic cholestasis type I (PFIC I) in a two-year-old boy was successfully managed with medical therapy. This Indian case highlights diagnostic and therapeutic challenges in treating this rare liver disorder.

Area of Science:

  • Hepatology
  • Pediatric Gastroenterology
  • Medical Genetics

Background:

  • Progressive familial intrahepatic cholestasis type I (PFIC I) is a rare genetic disorder affecting bile flow.
Keywords:
Progressive familial intrahepatic cholestasisalopeciabland cholestasisgranular bilepruritus

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  • Early diagnosis and management are crucial for improving patient outcomes.
  • Limited case reports exist, particularly from India, necessitating further documentation.