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From conventional therapy toward microRNA-based therapy in acute promyelocytic leukemia

Naeim Ehtesham1, Mohammadreza Sharifi1

  • 1Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Advanced Biomedical Research
|December 29, 2016
PubMed

Insights

Acute promyelocytic leukemia (APL), a blood cancer, is being explored for microRNA (miRNA) based diagnostics and therapeutics. Research is beginning to investigate miRNA-based treatments specifically for APL patients.

Area of Science:

  • Hematology
  • Oncology
  • Molecular Biology

Background:

  • Acute promyelocytic leukemia (APL) is a distinct subtype of hematopoietic malignancy characterized by unique cytogenetic features.
  • MicroRNAs (miRNAs) have emerged as significant molecules in cancer, with their expression patterns studied in various malignancies.
  • The potential of miRNAs as diagnostic and prognostic biomarkers across different cancers is a well-established area of research.

Conclusions:

  • MicroRNAs hold promise as biomarkers for Acute Promyelocytic Leukemia (APL).
  • The therapeutic application of miRNAs is a rapidly advancing field with potential for APL treatment.
  • Further research into miRNA-based therapies is crucial for developing novel treatment strategies for APL.
Keywords:
Acute promyelocytic leukemiacancer therapymicroRNAbased therapy

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