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Real world epidemiology of myeloproliferative neoplasms: a population based study in Korea 2004-2013
Ja Min Byun1, Young Jin Kim2, Taemi Youk3
1Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Abstract:
Myeloproliferative neoplasms (MPNs), with an expected increment in number, impose substantial economic and social burdens. To this end, we conducted a nationwide population-based descriptive epidemiology study. We also investigated medical cost associated with MPNs. Prevalence was the highest for essential thrombocythemia (ET) (range 4.1-9.0 per 100,000), followed by polycythemia vera (PV) (range 2.8-5.4 per 100,000) and primary myelofibrosis (PMF) (range 0.5-0.9 per 100,000). ET incurred the highest cumulative total cost at US$35 million and the most frequent hospital visits, while PMF incurred the highest average cost per person at US$5000. The mean hemoglobin level was 16.9 ± 2.2 g/dL for PV males and 15.5 ± 2.7 g/dL for PV females. Further analyses on hemoglobin levels showed the true positive rate of PV from the significantly elevated hemoglobin group (defined as >18.5 g/dL for men and >16.5 g/dL for women) was 3.01% and that of MPNs was 3.1%. Here, we provide the biggest population-based report on MPN epidemiology that can readily be used as a representative Asian data.
Insights
Myeloproliferative neoplasms (MPNs) impose significant burdens. This study details MPN prevalence, costs, and diagnostic rates in Asia, providing crucial epidemiological data.
Area of Science:
- Hematology
- Epidemiology
- Public Health
Background:
- Myeloproliferative neoplasms (MPNs) are increasing, posing economic and social challenges.
- Accurate epidemiological data is essential for resource allocation and healthcare planning.
Purpose of the Study:
- To conduct a nationwide, population-based epidemiological study of MPNs in Asia.
- To investigate the prevalence, medical costs, and diagnostic accuracy associated with MPNs.
Main Methods:
- Descriptive epidemiology study utilizing nationwide population data.
- Analysis of medical costs, hospital visit frequency, and hemoglobin levels.
- Calculation of true positive rates for polycythemia vera (PV) and MPNs based on elevated hemoglobin.
Main Results:
- Prevalence: Essential thrombocythemia (ET) highest (4.1-9.0/100,000), followed by Polycythemia Vera (PV) (2.8-5.4/100,000) and Primary Myelofibrosis (PMF) (0.5-0.9/100,000).
- Costs: ET incurred highest total cost ($35 million), PMF highest average cost ($5000/person).
- Diagnostics: True positive rate for PV and MPNs based on elevated hemoglobin was approximately 3%. Mean hemoglobin levels for PV were 16.9 g/dL (males) and 15.5 g/dL (females).
Conclusions:
- This study presents the largest population-based epidemiological data for MPNs in an Asian population.
- Findings highlight significant economic and social burdens associated with MPNs, particularly ET and PMF.
- The diagnostic accuracy based on hemoglobin levels suggests a need for refined screening strategies for MPNs.
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