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Evolution of diffusion tensor imaging parameters after acute subarachnoid haemorrhage: a prospective cohort study
Isabel Fragata1,2, Patrícia Canhão3,4, Marta Alves5
1Serviço de Neurorradiologia, Centro Hospitalar Lisboa Central, Hospital São José, Rua José António Serrano, Lisbon, 1150-045, Portugal. isabelfragata@gmail.com.
Neuroradiology
|December 29, 2016
Summary
Diffusion tensor imaging (DTI) showed subtle changes in acute subarachnoid haemorrhage (SAH) patients over time. While not linked to SAH severity, these DTI changes may indicate delayed cerebral ischemia (DCI).
Area of Science:
- Neuroimaging
- Neurology
- Radiology
Background:
- Diffusion tensor imaging (DTI) in acute subarachnoid haemorrhage (SAH) is understudied.
- Understanding DTI changes in early SAH is crucial for predicting outcomes.
Purpose of the Study:
- To prospectively evaluate DTI parameters in acute SAH.
- To analyze DTI changes in relation to SAH severity and delayed cerebral ischemia (DCI).
Main Methods:
- Prospective cohort study of acute SAH patients.
- Two MRI scans: <72 hours (MRI-1) and 8-10 days (MRI-2).
- Assessed apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in 15 ROIs using linear mixed regression models.
Main Results:
- Subtle DTI parameter changes observed between MRI-1 and MRI-2.
- Weak evidence of FA increase and ADC decrease in the posterior limb of the internal capsule (PLIC).
- Significant FA and ADC changes in the cerebellum; DCI patients showed trends towards lower FA/ADC, but not statistically significant.
Conclusions:
- DTI parameters (ADC, FA) exhibit subtle temporal changes in acute SAH, particularly in the PLIC and cerebellum.
- These DTI changes were not statistically associated with SAH severity or DCI occurrence.
- DTI alterations were more pronounced in DCI patients, suggesting potential as a DCI marker.
