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Related Experiment Video

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Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
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Migraine causes retinal and choroidal structural changes: evaluation with ocular coherence tomography.

Ester Reggio1, Clara G Chisari1, Giulia Ferrigno1

  • 1Department "G.F. Ingrassia" Section of Neuroscience, Policlinico G. Rodolico, University of Catania, via Santa Sofia 78, 95123, Catania, Italy.

Journal of Neurology
|December 29, 2016
PubMed
Summary

Migraine patients show reduced retinal nerve fiber layer (RNFL) and choroidal thickness (CT) compared to healthy individuals. Chronic migraineurs exhibit more significant retinal thinning, suggesting structural abnormalities beyond the brain.

Keywords:
ChoroidMigraineOcular coherence tomographyRetina

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Area of Science:

  • Ophthalmology
  • Neurology

Background:

  • Migraine's impact on the retina is under-researched, with conflicting findings on retinal nerve fiber layer (RNFL) thickness.
  • Ocular coherence tomography (OCT) allows detailed evaluation of retinal and choroidal structures.

Purpose of the Study:

  • To investigate retinal and choroidal involvement in migraine using OCT.
  • To compare ocular parameters between migraineurs (with and without aura, chronic migraine) and healthy controls.

Main Methods:

  • Case-control study involving 77 migraine patients and 42 healthy controls.
  • OCT imaging to measure RNFL, ganglion cell layer (GCL), foveal thickness (FT), choroidal thickness (CT), and total macular volume (TMV).
  • Statistical analysis to compare measurements between groups and assess correlations.

Main Results:

  • Migraine patients exhibited significantly thinner RNFL, GCL, and CT compared to healthy controls.
  • Chronic migraine patients showed greater reductions in RNFL and GCL compared to other migraine subtypes.
  • A significant inverse correlation was found between RNFL thickness and monthly headache frequency.

Conclusions:

  • The retina and choroid are involved in migraine, particularly in chronic migraine.
  • Chronic migraine may lead to permanent structural changes in the retina, suggesting a broader impact than previously understood.
  • Further research is warranted to explore the mechanisms and clinical implications of these findings.