Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Mar 9, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

Substituted tetrazoles as multipurpose screening compounds.

Nicole Rüger¹, Georg Michael Fassauer¹, Christian Bock¹

¹Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17487, Greifswald, Germany.

Molecular Diversity

|December 29, 2016

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

From Retigabine to Azetukalner: Reviving Voltage-Gated Potassium Channels for Epilepsy Therapy.

Archiv der Pharmazie·2026

Same author

Nanoplastics exacerbate cadmium toxicity in Mytilus coruscus through bioenergetic exhaustion and tissue disintegration.

Marine pollution bulletin·2026

Same author

¹H NMR Chemical Shifts and J-Coupling Constants Dependence on Temperature and pH: Implications for the Quantification of Relevant Metabolites.

NMR in biomedicine·2026

Same author

Acute warming combined with hypoxia and hypercapnia challenges but does not overwhelm Ostrea edulis passive tolerance mechanisms.

The Journal of experimental biology·2026

Same author

Psychological Safety Among Interprofessional Pediatric Oncology Teams in Germany: A Nationwide Survey.

Pediatric blood & cancer·2026

Same author

Psychological Safety in Pediatrics: A Scoping Review.

Klinische Padiatrie·2025

Same journal

Discovery of novel cinnamic acid derivatives with anti-Helicobacter pylori mechanism.

Molecular diversity·2026

Same journal

Tetrapeptide inhibitors of BACE-1 revealed by combined data-driven screening and physics-based free-energy refinement.

Molecular diversity·2026

Same journal

A cheminformatics and DFT exploration of a brominated sulfonamide with nonlinear optical response and preliminary in silico bioactivity assessment.

Molecular diversity·2026

Same journal

Triazoles as enzyme inhibitors: synthetic advances, mechanism of action, molecular docking studies and structure-activity relationships.

Molecular diversity·2026

Same journal

Synthesis of 9H-furo[2,3-f]chromenes using multicomponent reactions of euparin: investigation of biological activity.

Molecular diversity·2026

Same journal

Discovery of novel perillyl and myrtenyl nucleobase conjugates as dual anti-Alzheimer and antimicrobial agents.

Molecular diversity·2026

See all related articles

This study synthesizes novel polydentate tetrazole compounds for drug discovery. These compounds, rich in under-represented tetrazole derivatives, offer potential for targeting difficult or previously undruggable proteins.

Area of Science:

Medicinal Chemistry
Organic Synthesis
Drug Discovery

Background:

Tetrazoles are versatile heterocycles acting as aromatic platforms and interaction motifs.
Tetrazole derivatives can chelate metal ions, exhibiting diverse binding modes.
Previous work showed tetrazole-hydrazide fragments are effective for discovering selective screening hits.

Purpose of the Study:

To synthesize and characterize novel polydentate tetrazole-containing screening compounds.
To expand the chemical space of tetrazole derivatives available for drug discovery.
To deposit these compounds into a multipurpose screening library within the EU-OPENSCREEN network.

Main Methods:

Synthesis of tetrazole-containing compounds and their precursors.

Keywords:

High-throughput screening Hydrazides Hydrazones Metal complexing agents Open access data bank Targeted library

More Related Videos

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels

Published on: January 27, 2013

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

Related Experiment Videos

Last Updated: Mar 9, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels

Published on: January 27, 2013

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

Characterization of the synthesized compounds.

Deposition of pure compounds into a screening library.

Main Results:

Successful synthesis and characterization of new polydentate tetrazole screening compounds.
Availability of under-represented tetrazole derivatives for screening.
Compounds are deposited in a multipurpose screening library.

Conclusions:

The synthesized tetrazole compounds are well-characterized and suitable for drug discovery programs.
These novel compounds can aid in targeting multiple or previously undruggable protein targets.
The inclusion of under-represented tetrazole derivatives enriches the screening library.