Kinetics of cis-dichlorodiammine platinum (II) during plasmapheresis

The pharmacokinetics of cis-dichlorodiammineplatinum (II) (cisplatin) during double filtration plasmapheresis (PP) have been studied in ten patients who received the drug as a 30 min infusion. The patients receiving the drug exhibited biphase clearance of total platinum with a rapid initial phase (40 min) and a prolonged second phase (1-24 h). Free (ultrafiltrable) cisplatin was readily detectable and the clearance curve of free cisplatin was biphasic, with a short initial phase (1 h) and a long second phase (1-24 h). In conclusion, the loss of both total cisplatin and free cisplatin in serum were not found during plasmapheresis.