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A comparison of the clinical variations of the iridocorneal endothelial syndrome
1Department of Ophthalmology, Duke University Eye Center, Durham, NC 27710.
Insights
Iridocorneal endothelial syndrome has three subtypes: Chandler's, progressive iris atrophy, and Cogan-Reese. Chandler's syndrome patients experienced more corneal edema, while the other two subtypes showed worse secondary glaucoma.
Area of Science:
- Ophthalmology
- Corneal Diseases
- Glaucoma
Background:
- Iridocorneal endothelial syndrome (ICE) encompasses three recognized variations.
- Understanding the clinical distinctions between these subtypes is crucial for patient management.
Purpose of the Study:
- To compare the clinical presentation and disease course of Chandler's syndrome, progressive iris atrophy, and Cogan-Reese syndrome.
- To evaluate the clinical significance of the current classification of ICE syndrome.
Main Methods:
- Retrospective review of medical records from 37 consecutive patients diagnosed with ICE syndrome.
- Comparison of clinical features, specifically corneal edema and secondary glaucoma, across the three ICE syndrome subgroups.
Main Results:
- Chandler's syndrome was the most frequent subtype (21 cases).
- Patients with Chandler's syndrome exhibited more severe corneal edema compared to other subtypes.
- Progressive iris atrophy and Cogan-Reese syndrome (8 cases each) were associated with more severe secondary glaucoma.
Conclusions:
- The three subtypes of iridocorneal endothelial syndrome present with distinct clinical characteristics.
- Chandler's syndrome is primarily associated with corneal edema, whereas progressive iris atrophy and Cogan-Reese syndrome are linked to secondary glaucoma.
Abstract:
Iridocorneal endothelial syndrome is generally considered to have three major variations: Chandler's syndrome, progressive (essential) iris atrophy, and the Cogan-Reese syndrome. To better understand the clinical significance of this classification, we studied the medical records of 37 consecutive patients from our practice, comparing the presentation and course of the three subgroups. Chandler's syndrome was the most common clinical variant within this spectrum of disease (21 cases). Patients with Chandler's syndrome had more severe corneal edema than the rest of the group, while those with progressive iris atrophy (8 cases) or the Cogan-Reese syndrome (8 cases) had worse secondary glaucoma.