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Expression of maspin in invasive fungal rhinosinusitis
1Department of Otolaryngology - Head and Neck Surgery,PLA 118 Hospital,Wenzhou,Zhejiang Province.
Objective:
This study aimed to test the expression of maspin in invasive fungal rhinosinusitis and explore its value in diagnosing invasive fungal rhinosinusitis.
Methods:
Forty-two fungal rhinosinusitis cases (12 invasive and 30 non-invasive) were selected as the experimental group, and 30 chronic rhinosinusitis cases comprised the control group. Maspin expression was assessed in nasal mucous membrane specimens by immunohistochemical staining.
Results:
Compared with the control group, maspin expression was down-regulated in the fungal rhinosinusitis group (p < 0.05). Furthermore, the staining score for maspin was lowest in the invasive fungal rhinosinusitis group, as compared with both the non-invasive fungal rhinosinusitis group and the control group (p < 0.05). A maspin staining score of 5.70 was the critical value for diagnosis of invasive fungal rhinosinusitis, with sensitivity and specificity of 91.7 per cent and 88.3 per cent, respectively.
Conclusion:
The results of this study suggest that the maspin staining score may be a biomarker for effective and rapid diagnosis of invasive fungal rhinosinusitis.
Insights
Maspin expression is down-regulated in fungal rhinosinusitis, particularly in invasive cases. Maspin staining scores show promise as a biomarker for diagnosing invasive fungal rhinosinusitis.
Area of Science:
- Otorhinolaryngology
- Oncology
- Immunology
Background:
- Invasive fungal rhinosinusitis (IFR) presents diagnostic challenges.
- Maspin, a tumor suppressor protein, has potential roles in various diseases.
Purpose of the Study:
- To evaluate maspin expression in IFR.
- To determine the diagnostic value of maspin for IFR.
Main Methods:
- Immunohistochemical staining was used to assess maspin expression.
- Maspin levels were compared between IFR, non-invasive fungal rhinosinusitis, and chronic rhinosinusitis groups.
Main Results:
- Maspin expression was significantly lower in fungal rhinosinusitis compared to controls.
- The lowest maspin staining scores were observed in the IFR group.
- A maspin score cutoff of 5.70 demonstrated high sensitivity (91.7%) and specificity (88.3%) for IFR diagnosis.
Conclusions:
- Maspin expression is down-regulated in IFR.
- Maspin serves as a potential biomarker for the rapid and effective diagnosis of IFR.
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