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Updated: Mar 9, 2026

DNA-affinity-purified Chip DAP-chip Method to Determine Gene Targets for Bacterial Two component Regulatory Systems
Published on: July 21, 2014
dAPE: a web server to detect homorepeats and follow their evolution
Homorepeats are low-complexity protein regions. The dAPE web server aids in tracking homorepeat evolution using orthology, identifying new homorepeats with a tunable cutoff.
Area of Science:
- Proteomics and bioinformatics
- Evolutionary biology
Background:
- Homorepeats are protein regions with repetitive single amino acid residues.
- The definition of a functional homorepeat, including minimum length and allowance for mismatches, lacks consensus.
Purpose of the Study:
- To present dAPE, a novel web server for analyzing homorepeat evolution.
- To facilitate the identification of emerging homorepeats by leveraging orthology information.
Main Methods:
- Utilizing orthology information to trace homorepeat evolution.
- Implementing a sensitive yet tunable cutoff for homorepeat identification.
Main Results:
- dAPE provides a tool to follow the evolutionary trajectory of homorepeats.
- The server aids in the discovery of potentially novel or emerging homorepeat structures.
Conclusions:
- dAPE offers a valuable resource for studying homorepeat dynamics.
- The tunable cutoff assists in defining and identifying homorepeats in an evolutionary context.
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