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Remarkable bone formation following gefitinib for extensive lytic bone metastasis: a report of two cases

Elrofai Suliman Bashir¹, Angel Khor Nee Kwan², Chris Yin Wei Chan²

¹Elneelain University, Faculty of Medicine, Khartoum, Sudan.

Journal of Orthopaedic Surgery (Hong Kong)

|December 30, 2016

Abstract:

Gefitinib inhibits the epidermal growth factor receptor tyrosine kinase and improves survival in patients with non-small-cell lung cancer. We report 2 patients with extensive lytic bony metastasis in the spine and pelvis secondary to advanced pulmonary adenocarcinoma who were treated with gefitinib and had remarkable bone formation in the lytic bone lesions in the spine and pelvis. Surgery for stabilisation was avoided.

Keywords:

adenocarcinoma of lung bone cysts gefitinib neoplasm metastasis receptor, epidermal growth factor

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