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Related Concept Videos

Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

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Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
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Antihypertensive Drugs: Vasodilators01:23

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Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
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Antianginal Drugs: Nitrates and β-Blockers01:16

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In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates,  such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
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Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

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Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
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Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

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Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
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Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

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Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
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Related Experiment Video

Updated: Mar 9, 2026

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
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Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

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Nitric oxide therapy for dermatologic disease.

Brandon L Adler1, Adam J Friedman2

  • 1Department of Medicine (Division of Dermatology), Albert Einstein College of Medicine, Bronx, NY, USA; Department of Medicine (Division of Dermatology), Albert Einstein College of Medicine, Bronx, NY, USA.

Future Science OA
|December 30, 2016
PubMed
Summary
This summary is machine-generated.

Nitric oxide (NO) shows promise as a topical antimicrobial agent for skin infections, with a low risk of resistance. This review explores NO

Keywords:
NOSRNOSSSTIcosmeceuticalnitric oxide synthasereactive nitrogen oxide speciesskin and soft-tissue infection

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Area of Science:

  • Dermatology and Microbiology
  • Biomedical Sciences

Background:

  • Nitric oxide (NO) is crucial for skin health and integrity.
  • Dysregulation of NO production is linked to various dermatologic diseases.
  • Rising antibiotic resistance necessitates novel therapeutic strategies.

Approach:

  • Review of NO's role in skin physiology and pathology.
  • Focus on NO as a topical antimicrobial for skin and soft-tissue infections.
  • Examination of NO's immunomodulatory functions.
  • Analysis of topical NO delivery systems.
  • Exploration of NO's interaction with UV radiation and pigmentation.
  • Assessment of NO's potential in cosmeceuticals.

Key Points:

  • NO demonstrates broad-spectrum antimicrobial activity with low resistance potential.
  • NO plays a significant role in skin immune function and regulation.
  • Various topical delivery systems for NO are under development and testing.

Conclusions:

  • Topical nitric oxide (NO) presents a promising therapeutic avenue for dermatologic conditions, particularly infections.
  • Further research into NO's multifaceted roles in skin biology and its delivery systems could unlock significant clinical and cosmetic applications.