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Related Concept Videos

Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

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Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

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Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
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Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
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Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
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Related Experiment Video

Updated: Mar 9, 2026

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
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Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

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Nitric oxide for cancer therapy.

Sergio Huerta1

  • 1Department of Surgery, UT Southwestern Medical Center, VA North Texas Health Care System, 4500 S. Lancaster Rd./Surgical Services (112)/Dallas, TX 75216, USA.

Future Science OA
|December 30, 2016
PubMed
Summary

High doses of nitric oxide (NO) show promise in cancer therapy, potentially overcoming resistance to conventional treatments. NO donors are explored as a strategy to enhance antineoplastic compound efficacy.

Area of Science:

  • Oncology
  • Biomedical Science
  • Cancer Therapeutics

Background:

  • Tumor resistance to current cancer treatments is a significant clinical challenge.
  • Nitric oxide (NO) has demonstrated dual roles in cancer, with potential proneoplastic properties.
  • Emerging evidence highlights the therapeutic potential of high-dose NO in cancer treatment.

Conclusions:

  • Nitric oxide (NO) plays a critical role in cancer therapeutics, particularly at high doses.
  • The use of NO donors offers a promising strategy to combat tumor resistance.
  • Further research into NO-based therapies could revolutionize cancer treatment paradigms.
Keywords:
JSKNO donorsNO hybridsdiazeniumdiolates

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