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Nitric Oxide Signaling Pathway

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Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...

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Related Experiment Video

Updated: Mar 9, 2026

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

Nitric oxide enhancement strategies.

Nathan S Bryan¹

¹Department of Molecular & Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.

Future Science OA

|December 30, 2016

Summary

Restoring nitric oxide (NO) balance is key for treating various diseases. This review explores strategies for enhancing NO production or availability for therapeutic applications.

Area of Science:

Biomedical Science
Pharmacology
Physiology

Background:

Perturbations in nitric oxide (NO) production/signaling are linked to numerous diseases.
Restoring NO homeostasis presents broad therapeutic potential.
The complex NO pathway offers multiple targets for drug development.

Approach:

Summarizes current and developing strategies to enhance NO production or availability.
Discusses exogenous NO sources, NO precursor utilization, and downstream pathway modulation.
Highlights advantages and disadvantages of each therapeutic strategy.

Key Points:

Nitric oxide (NO) plays a crucial role in physiological processes.
Dysregulation of NO signaling is implicated in cardiovascular disease, cancer, and infections.

Keywords:

guanylyl cyclase nanotechnology nitrate nitric oxide nitrite nitrosothiols

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En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries

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Preparation of Rat Skeletal Muscle Homogenates for Nitrate and Nitrite Measurements

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Last Updated: Mar 9, 2026

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries

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Preparation of Rat Skeletal Muscle Homogenates for Nitrate and Nitrite Measurements

Preparation of Rat Skeletal Muscle Homogenates for Nitrate and Nitrite Measurements

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Therapeutic strategies aim to boost NO levels or signaling efficacy.

Conclusions:

Nitric oxide-based therapeutics are a major focus for pharmaceutical and academic research.
Developing safe and effective NO-enhancing strategies promises to significantly impact health and disease management.
Targeting NO pathways offers a transformative approach to treating a wide range of conditions.