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Updated: Mar 9, 2026
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
Photodynamic therapy and imaging based on tumor-targeted nanoprobe, polymer-conjugated zinc protoporphyrin
Jun Fang1, Long Liao2, Hongzhuan Yin3
1Research Institute for Drug Delivery Science, Sojo University, Ikeda 4-22-1, Kumamoto 860-0082, Japan; Laboratory of Microbiology & Oncology, Faculty of Pharmaceutical Science, Sojo University, Kumamoto, Japan; Research Institute for Drug Delivery Science, Sojo University, Ikeda 4-22-1, Kumamoto 860-0082, Japan; Laboratory of Microbiology & Oncology, Faculty of Pharmaceutical Science, Sojo University, Kumamoto, Japan.
Aim:
To evaluate the potential of tumor-targeted nanoprobe, N-(2-hydroxypropyl)methacrylamide copolymer-conjugated zinc protoporphyrin (PZP) for photodynamic therapy (PDT) and tumor imaging.
Materials & Methods:
Different tumor models including carcinogen-induced cancer were used, PZP was intravenously injected followed by irradiation with xenon or blue fluorescent light on tumor.
Results:
One PZP 20 mg/kg (ZnPP equivalent) dose with two or three treatments of light at an intensity of ≥20 J/cm2 caused necrosis and disappearance of most tumors (>70%) in different tumor models. We also confirmed PZP-based tumor imaging in carcinogen-induced breast tumor and colon cancer models.
Conclusion:
These findings support the potential application of PZP as a tumor-selective nanoprobe for PDT as well as tumor imaging, by virtue of the enhanced permeability and retention effect.
