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Updated: Mar 9, 2026
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
Invertible micellar polymer nanoassemblies target bone tumor cells but not normal osteoblast cells
Olena Kudina1, Kristen L Shogren2, Carl T Gustafson2
1Department of Coatings & Polymeric Materials, North Dakota State University, Fargo, ND 58105-6050, USA (currently Department of Science & Technology University of Twente, the Netherlands); Department of Coatings & Polymeric Materials, North Dakota State University, Fargo, ND 58105-6050, USA (currently Department of Science & Technology University of Twente, the Netherlands).
Aim:
To demonstrate the capability of the invertible micellar polymer nanoassemblies (IMAs) to deliver and release curcumin using the recently discovered mechanism of macromolecular inversion to treat bone tumor cells.
Materials & Methods:
The effect of IMA-mediated delivery of curcumin on osteosarcoma cell survival was investigated using MTS assays. To assess the effect of IMAs-delivered curcumin on osteosarcoma cell growth, fluorescence-activated cell sorting was performed. The uptake of micellar nanoassemblies was followed using confocal microscopy.
Results & Discussion:
IMAs-delivered curcumin is effective in blocking osteosarcoma cell growth. It decreases cell viability in human osteosarcoma (MG63, KHOS, and LM7) cells while having no effect on normal human osteoblast cells. It indicates that curcumin-loaded IMAs provide a unique delivery system targeted to osteosarcoma cells.
