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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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The impact of blood shear rate on arterial thrombus formation

Kjell S Sakariassen1, Lars Orning2, Vincent T Turitto3

  • 1KellSa s.a.s., Str. Campo e Zampo 12, I-13900 Biella, BI, Italy; KellSa s.a.s., Str. Campo e Zampo 12, I-13900 Biella, BI, Italy.

Future Science OA
|December 30, 2016
PubMed

The shear rate and corresponding shear stress have impacts on arterial thrombus formation. In particular, the effects of increasing concentration of platelets at the vessel wall and activation of platelets at this site increase the growth and stability of the thrombi which may result in a fatal narrowing of the arterial lumen. The efficacy of many antithrombotic agents is shear dependent as well. It is apparent that there is a need for a point-of-care device to rapidly monitor the risk for arterial thrombosis and to optimize antithrombotic therapy in vitro. The present review focuses on the essential role of shear rate on arterial thrombus formation in native human blood drawn directly from an antecubital vein.

Keywords:
arterial stenosisplatelet activationplatelet adhesionplatelet aggregationshear rateshear stress

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